Iridium-catalyzed enantioselective synthesis of chiral γ-amino alcohols and intermediates of (S)-duloxetine, (R)-fluoxetine, and (R)-atomoxetine

Chiral γ-amino alcohols are the prevalent structural motifs and building blocks in pharmaceuticals and bioactive molecules. Enantioselective hydrogenation of β-amino ketones provides a straightforward and powerful tool for the synthesis of chiral γ-amino alcohols, but the asymmetric transformation i...

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Detalles Bibliográficos
Autores principales: Liu, Chengyu, Zhang, Lei, Cao, Liming, Xiong, Yan, Ma, Yueyue, Cheng, Ruihua, Ye, Jinxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814375/
https://www.ncbi.nlm.nih.gov/pubmed/36697664
http://dx.doi.org/10.1038/s42004-022-00678-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814375/
https://www.ncbi.nlm.nih.gov/pubmed/36697664
http://dx.doi.org/10.1038/s42004-022-00678-4

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