Binding-driven reactivity attenuation enables NMR identification of selective drug candidates for nucleic acid targets

NMR methods, and in particular ligand-based approaches, are among the most robust and reliable alternatives for binding detection and consequently, they have become highly popular in the context of hit identification and drug discovery. However, when dealing with DNA/RNA targets, these techniques fa...

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Detalles Bibliográficos
Autores principales: Díaz-Casado, Laura, Santana, Andrés G., Gómez-Pinto, Irene, Villacampa, Alejandro, Corzana, Francisco, Jiménez-Barbero, Jesús, González, Carlos, Asensio, Juan Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814457/
https://www.ncbi.nlm.nih.gov/pubmed/36697799
http://dx.doi.org/10.1038/s42004-022-00755-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814457/
https://www.ncbi.nlm.nih.gov/pubmed/36697799
http://dx.doi.org/10.1038/s42004-022-00755-8

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