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Binding-driven reactivity attenuation enables NMR identification of selective drug candidates for nucleic acid targets
NMR methods, and in particular ligand-based approaches, are among the most robust and reliable alternatives for binding detection and consequently, they have become highly popular in the context of hit identification and drug discovery. However, when dealing with DNA/RNA targets, these techniques fa...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814457/ https://www.ncbi.nlm.nih.gov/pubmed/36697799 http://dx.doi.org/10.1038/s42004-022-00755-8 |