ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth

Activation of receptor tyrosine kinase signaling inactivates capicua (CIC), a transcriptional repressor that functions as a tumor suppressor, via degradation and/or cytoplasmic translocation. Although CIC is known to be inactivated by phosphorylation, the mechanisms underlying the cytoplasmic transl...

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Detalles Bibliográficos
Autores principales: Park, Jongmin, Park, Guk-Yeol, Lee, Jongeun, Park, Joonyoung, Kim, Soeun, Kim, Eunjeong, Park, Seung-Yeol, Yoon, Jong Hyuk, Lee, Yoontae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814488/
https://www.ncbi.nlm.nih.gov/pubmed/36619173
http://dx.doi.org/10.3389/fmolb.2022.1030725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814488/
https://www.ncbi.nlm.nih.gov/pubmed/36619173
http://dx.doi.org/10.3389/fmolb.2022.1030725

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