A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state

The C-type lectin family member lectin-like oxidized LDL receptor-1 (LOX-1) has been object of intensive research. Its modulation may offer a broad spectrum of therapeutic interventions ranging from cardiovascular diseases to cancer. LOX-1 mediates uptake of oxLDL by vascular cells and plays an impo...

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Detalles Bibliográficos
Autores principales: Schnapp, Gisela, Neubauer, Heike, Büttner, Frank H., Handschuh, Sandra, Lingard, Iain, Heilker, Ralf, Klinder, Klaus, Prestle, Jürgen, Walter, Rainer, Wolff, Michael, Zeeb, Markus, Debaene, Francois, Nar, Herbert, Fiegen, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814544/
https://www.ncbi.nlm.nih.gov/pubmed/36703453
http://dx.doi.org/10.1038/s42004-020-0321-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814544/
https://www.ncbi.nlm.nih.gov/pubmed/36703453
http://dx.doi.org/10.1038/s42004-020-0321-2

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