Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor

Inhibitors for membrane transporters have been shown to be indispensable as drugs and tool compounds. The proton-dependent oligopeptide transporters PEPT1 and PEPT2 from the SLC15 family play important roles in human and mammalian physiology. With Lys[Z(NO(2))]-Val (LZNV), a modified Lys-Val dipepti...

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Detalles Bibliográficos
Autores principales: Stauffer, Mirko, Jeckelmann, Jean-Marc, Ilgü, Hüseyin, Ucurum, Zöhre, Boggavarapu, Rajendra, Fotiadis, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814568/
https://www.ncbi.nlm.nih.gov/pubmed/36697632
http://dx.doi.org/10.1038/s42004-022-00636-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814568/
https://www.ncbi.nlm.nih.gov/pubmed/36697632
http://dx.doi.org/10.1038/s42004-022-00636-0

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