Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism

Landomycins are angucyclines with promising antineoplastic activity produced by Streptomyces bacteria. The aglycone landomycinone is the distinctive core, while the oligosaccharide chain differs within derivatives. Herein, we report that landomycins spontaneously form Michael adducts with biothiols,...

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Detalles Bibliográficos
Autores principales: Terenzi, Alessio, La Franca, Mery, van Schoonhoven, Sushilla, Panchuk, Rostyslav, Martínez, Álvaro, Heffeter, Petra, Gober, Redding, Pirker, Christine, Vician, Petra, Kowol, Christian R., Stoika, Rostyslav, Salassa, Luca, Rohr, Jürgen, Berger, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814637/
https://www.ncbi.nlm.nih.gov/pubmed/36697631
http://dx.doi.org/10.1038/s42004-021-00600-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814637/
https://www.ncbi.nlm.nih.gov/pubmed/36697631
http://dx.doi.org/10.1038/s42004-021-00600-4

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