Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter

The aggregation of α-synuclein is a central event in Parkinsons’s disease and related synucleinopathies. Since pharmacologically targeting this process, however, has not yet resulted in approved disease-modifying treatments, there is an unmet need of developing novel methods of drug discovery. In th...

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Detalles Bibliográficos
Autores principales: Staats, Roxine, Michaels, Thomas C. T., Flagmeier, Patrick, Chia, Sean, Horne, Robert I., Habchi, Johnny, Linse, Sara, Knowles, Tuomas P. J., Dobson, Christopher M., Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814678/
https://www.ncbi.nlm.nih.gov/pubmed/36703335
http://dx.doi.org/10.1038/s42004-020-00412-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814678/
https://www.ncbi.nlm.nih.gov/pubmed/36703335
http://dx.doi.org/10.1038/s42004-020-00412-y

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