Quantifying the binding landscapes of protein–protein interactions

Small changes in protein structure can have pronounced effects on protein–protein interactions, but quantifying this has only recently become possible. Now, the binding landscapes of three homologous enzyme–inhibitor complexes are quantified and shown to depend on whether the inhibitor binds its nat...

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Autor principal: Bissette, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814691/
https://www.ncbi.nlm.nih.gov/pubmed/36697583
http://dx.doi.org/10.1038/s42004-021-00608-w
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author Bissette, Andrew J.
author_facet Bissette, Andrew J.
author_sort Bissette, Andrew J.
collection PubMed
description Small changes in protein structure can have pronounced effects on protein–protein interactions, but quantifying this has only recently become possible. Now, the binding landscapes of three homologous enzyme–inhibitor complexes are quantified and shown to depend on whether the inhibitor binds its natural target or a structurally similar protein.
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spelling pubmed-98146912023-01-10 Quantifying the binding landscapes of protein–protein interactions Bissette, Andrew J. Commun Chem Research Highlight Small changes in protein structure can have pronounced effects on protein–protein interactions, but quantifying this has only recently become possible. Now, the binding landscapes of three homologous enzyme–inhibitor complexes are quantified and shown to depend on whether the inhibitor binds its natural target or a structurally similar protein. Nature Publishing Group UK 2021-11-26 /pmc/articles/PMC9814691/ /pubmed/36697583 http://dx.doi.org/10.1038/s42004-021-00608-w Text en © Springer Nature Limited 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Highlight
Bissette, Andrew J.
Quantifying the binding landscapes of protein–protein interactions
title Quantifying the binding landscapes of protein–protein interactions
title_full Quantifying the binding landscapes of protein–protein interactions
title_fullStr Quantifying the binding landscapes of protein–protein interactions
title_full_unstemmed Quantifying the binding landscapes of protein–protein interactions
title_short Quantifying the binding landscapes of protein–protein interactions
title_sort quantifying the binding landscapes of protein–protein interactions
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814691/
https://www.ncbi.nlm.nih.gov/pubmed/36697583
http://dx.doi.org/10.1038/s42004-021-00608-w
work_keys_str_mv AT bissetteandrewj quantifyingthebindinglandscapesofproteinproteininteractions

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