Mechanistic basis of the increased methylation activity of the SETD2 protein lysine methyltransferase towards a designed super-substrate peptide

Protein lysine methyltransferases have important regulatory functions in cells, but mechanisms determining their activity and specificity are incompletely understood. Naturally, SETD2 introduces H3K36me3, but previously an artificial super-substrate (ssK36) was identified, which is methylated >10...

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Detalles Bibliográficos
Autores principales: Schnee, Philipp, Choudalakis, Michel, Weirich, Sara, Khella, Mina S., Carvalho, Henrique, Pleiss, Jürgen, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814698/
https://www.ncbi.nlm.nih.gov/pubmed/36697904
http://dx.doi.org/10.1038/s42004-022-00753-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814698/
https://www.ncbi.nlm.nih.gov/pubmed/36697904
http://dx.doi.org/10.1038/s42004-022-00753-w

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