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Structure of an anti-PEG antibody reveals an open ring that captures highly flexible PEG polymers

Polyethylene glycol (PEG) is a polymer routinely used to modify biologics and nanoparticles to prolong blood circulation and reduce immunogenicity of the underlying therapeutic. However, several PEGylated therapeutics induce the development of anti-PEG antibodies (APA), leading to reduced efficacy a...

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Detalles Bibliográficos
Autores principales: Huckaby, Justin T., Jacobs, Tim M., Li, Zhongbo, Perna, Robert J., Wang, Anting, Nicely, Nathan I., Lai, Samuel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814744/
https://www.ncbi.nlm.nih.gov/pubmed/36703348
http://dx.doi.org/10.1038/s42004-020-00369-y