Amino acid dependent formaldehyde metabolism in mammals

Aldehyde dehydrogenase class 3, encoded by ADH5 in humans, catalyzes the glutathione dependent detoxification of formaldehyde. Here we show that ADH5 deficient cells turn over formaldehyde using alternative pathways starting from the reaction of formaldehyde with free amino acids. When mammalian cel...

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Detalles Bibliográficos
Autores principales: Pietzke, Matthias, Burgos-Barragan, Guillermo, Wit, Niek, Tait-Mulder, Jacqueline, Sumpton, David, Mackay, Gillian M., Patel, Ketan J., Vazquez, Alexei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814826/
https://www.ncbi.nlm.nih.gov/pubmed/36703413
http://dx.doi.org/10.1038/s42004-020-0324-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814826/
https://www.ncbi.nlm.nih.gov/pubmed/36703413
http://dx.doi.org/10.1038/s42004-020-0324-z

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