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Simultaneous sensing and imaging of individual biomolecular complexes enabled by modular DNA–protein coupling
Many proteins form dynamic complexes with DNA, RNA, and other proteins, which often involves protein conformational changes that are key to function. Yet, methods to probe these critical dynamics are scarce. Here we combine optical tweezers with fluorescence imaging to simultaneously monitor the con...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814868/ https://www.ncbi.nlm.nih.gov/pubmed/36703465 http://dx.doi.org/10.1038/s42004-020-0267-4 |