Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures

Fragment based methods are now widely used to identify starting points in drug discovery and generation of tools for chemical biology. A significant challenge is optimization of these weak binding fragments to hit and lead compounds. We have developed an approach where individual reaction mixtures o...

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Detalles Bibliográficos
Autores principales: Baker, Lisa M., Aimon, Anthony, Murray, James B., Surgenor, Allan E., Matassova, Natalia, Roughley, Stephen D., Collins, Patrick M., Krojer, Tobias, von Delft, Frank, Hubbard, Roderick E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814918/
https://www.ncbi.nlm.nih.gov/pubmed/36703375
http://dx.doi.org/10.1038/s42004-020-00367-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814918/
https://www.ncbi.nlm.nih.gov/pubmed/36703375
http://dx.doi.org/10.1038/s42004-020-00367-0

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