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Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures
Fragment based methods are now widely used to identify starting points in drug discovery and generation of tools for chemical biology. A significant challenge is optimization of these weak binding fragments to hit and lead compounds. We have developed an approach where individual reaction mixtures o...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814918/ https://www.ncbi.nlm.nih.gov/pubmed/36703375 http://dx.doi.org/10.1038/s42004-020-00367-0 |