MiR-451a and let-7i-5p loaded extracellular vesicles attenuate heme-induced inflammation in hiPSC-derived endothelial cells

Hemolysis is associated with many pathologies, including trauma, sepsis, hemorrhagic stroke, malaria, and genetic disorders such as sickle cell disease (SCD). When hemolysis occurs, free-heme drives vascular inflammation, resulting in oxidative tissue damage and cardiometabolic complications. A bett...

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Detalles Bibliográficos
Autores principales: Thomas, Justin J., Harp, Keri Oxendine, Bashi, Alaijah, Hood, Joshua L., Botchway, Felix, Wilson, Michael D., Thompson, Winston E., Stiles, Jonathan K., Driss, Adel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815029/
https://www.ncbi.nlm.nih.gov/pubmed/36618355
http://dx.doi.org/10.3389/fimmu.2022.1082414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815029/
https://www.ncbi.nlm.nih.gov/pubmed/36618355
http://dx.doi.org/10.3389/fimmu.2022.1082414

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