Tumor CEMIP drives immune evasion of colorectal cancer via MHC-I internalization and degradation

BACKGROUND: Loss of major histocompatibility complex class I (MHC-I) in tumor cells limits the use of immune checkpoint blockade (ICB) in colorectal cancer. Nevertheless, the regulatory mechanism of MHC-I downregulation in tumor cells has not been fully elucidated. Overexpression of CEMIP in tumor t...

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Detalles Bibliográficos
Autores principales: Zhang, Biying, Li, Jiao, Hua, Qingling, Wang, Haihong, Xu, Guojie, Chen, Jiayuan, Zhu, Ying, Li, Ruiqi, Liang, Qing, Wang, Lanqing, Jin, Min, Tang, Jing, Lin, Zhenyu, Zhao, Lei, Zhang, Dejun, Yu, Dandan, Ren, Jinghua, Zhang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815088/
https://www.ncbi.nlm.nih.gov/pubmed/36596591
http://dx.doi.org/10.1136/jitc-2022-005592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815088/
https://www.ncbi.nlm.nih.gov/pubmed/36596591
http://dx.doi.org/10.1136/jitc-2022-005592

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