Crystal structure of a covalently linked Aurora-A–MYCN complex

Formation of the Aurora-A–MYCN complex increases levels of the oncogenic transcription factor MYCN in neuroblastoma cells by abrogating its degradation through the ubiquitin proteasome system. While some small-molecule inhibitors of Aurora-A were shown to destabilize MYCN, clinical trials have not b...

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Detalles Bibliográficos
Autores principales: Diebold, Mathias, Schönemann, Lars, Eilers, Martin, Sotriffer, Christoph, Schindelin, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2023
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815099/
https://www.ncbi.nlm.nih.gov/pubmed/36601802
http://dx.doi.org/10.1107/S2059798322011433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815099/
https://www.ncbi.nlm.nih.gov/pubmed/36601802
http://dx.doi.org/10.1107/S2059798322011433

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