Apigenin directly interacts with and inhibits topoisomerase 1 to upregulate CD26/DPP4 on colorectal carcinoma cells

Introduction: CD26/dipeptidyl peptidase IV (DPP4) is a cell-surface glycoprotein present on most epithelial cells that modulates the local response to external signals. We have previously shown that the dietary flavone apigenin (4′,5,7-trihydroxyflavone) upregulates cell-surface CD26/DPP4 on human c...

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Detalles Bibliográficos
Autores principales: Fux, Julia E., Lefort, Émilie C., Rao, Praveen P. N., Blay, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815539/
https://www.ncbi.nlm.nih.gov/pubmed/36618939
http://dx.doi.org/10.3389/fphar.2022.1086894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815539/
https://www.ncbi.nlm.nih.gov/pubmed/36618939
http://dx.doi.org/10.3389/fphar.2022.1086894

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