Allosteric regulation in STAT3 interdomains is mediated by a rigid core: SH2 domain regulation by CCD in D170A variant

Signal Transducer and Activator of Transcription 3 (STAT3) plays a crucial role in cancer development and thus is a viable target for cancer treatment. STAT3 functions as a dimer mediated by phosphorylation of the SRC-homology 2 (SH2) domain, a key target for therapeutic drugs. While great efforts h...

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Detalles Bibliográficos
Autores principales: Zhao, Tingting, Karki, Nischal, Zoltowski, Brian D., Matthews, Devin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815575/
https://www.ncbi.nlm.nih.gov/pubmed/36542668
http://dx.doi.org/10.1371/journal.pcbi.1010794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815575/
https://www.ncbi.nlm.nih.gov/pubmed/36542668
http://dx.doi.org/10.1371/journal.pcbi.1010794

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