A scalable model for simulating multi-round antibody evolution and benchmarking of clonal tree reconstruction methods

Affinity maturation (AM) of B cells through somatic hypermutations (SHMs) enables the immune system to evolve to recognize diverse pathogens. The accumulation of SHMs leads to the formation of clonal lineages of antibody-secreting b cells that have evolved from a common naïve B cell. Advances in hig...

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Detalles Bibliográficos
Autores principales: Zhang, Chao, Bzikadze, Andrey V., Safonova, Yana, Mirarab, Siavash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815712/
https://www.ncbi.nlm.nih.gov/pubmed/36618367
http://dx.doi.org/10.3389/fimmu.2022.1014439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815712/
https://www.ncbi.nlm.nih.gov/pubmed/36618367
http://dx.doi.org/10.3389/fimmu.2022.1014439

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