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A scalable model for simulating multi-round antibody evolution and benchmarking of clonal tree reconstruction methods
Affinity maturation (AM) of B cells through somatic hypermutations (SHMs) enables the immune system to evolve to recognize diverse pathogens. The accumulation of SHMs leads to the formation of clonal lineages of antibody-secreting b cells that have evolved from a common naïve B cell. Advances in hig...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815712/ https://www.ncbi.nlm.nih.gov/pubmed/36618367 http://dx.doi.org/10.3389/fimmu.2022.1014439 |