A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0

We present a new approach for macromolecular structure determination from multiple particles in electron cryo-tomography (cryo-ET) data sets. Whereas existing subtomogram averaging approaches are based on 3D data models, we propose to optimise a regularised likelihood target that approximates a func...

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Detalles Bibliográficos
Autores principales: Zivanov, Jasenko, Otón, Joaquín, Ke, Zunlong, von Kügelgen, Andriko, Pyle, Euan, Qu, Kun, Morado, Dustin, Castaño-Díez, Daniel, Zanetti, Giulia, Bharat, Tanmay AM, Briggs, John AG, Scheres, Sjors HW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815803/
https://www.ncbi.nlm.nih.gov/pubmed/36468689
http://dx.doi.org/10.7554/eLife.83724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815803/
https://www.ncbi.nlm.nih.gov/pubmed/36468689
http://dx.doi.org/10.7554/eLife.83724

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