Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction

The tumor suppressor gene PTEN is the second most commonly deleted gene in cancer. Such deletions often include portions of the chromosome 10q23 locus beyond the bounds of PTEN itself, which frequently disrupts adjacent genes. Coincidental loss of PTEN-adjacent genes might impose vulnerabilities tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Winter, Jacob M, Fresenius, Heidi L, Cunningham, Corey N, Wei, Peng, Keys, Heather R, Berg, Jordan, Bott, Alex, Yadav, Tarun, Ryan, Jeremy, Sirohi, Deepika, Tripp, Sheryl R, Barta, Paige, Agarwal, Neeraj, Letai, Anthony, Sabatini, David M, Wohlever, Matthew L, Rutter, Jared
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815822/
https://www.ncbi.nlm.nih.gov/pubmed/36409067
http://dx.doi.org/10.7554/eLife.82860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9815822/
https://www.ncbi.nlm.nih.gov/pubmed/36409067
http://dx.doi.org/10.7554/eLife.82860

Ejemplares similares