Targeting tumor-stroma communication by blocking endothelin-1 receptors sensitizes high-grade serous ovarian cancer to PARP inhibition

PARP inhibitors (PARPi) have changed the treatment paradigm of high-grade serous ovarian cancer (HG-SOC). However, the impact of this class of inhibitors in HG-SOC patients with a high rate of TP53 mutations is limited, highlighting the need to develop combinatorial therapeutic strategies to improve...

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Detalles Bibliográficos
Autores principales: Tocci, Piera, Roman, Celia, Sestito, Rosanna, Di Castro, Valeriana, Sacconi, Andrea, Molineris, Ivan, Paolini, Francesca, Carosi, Mariantonia, Tonon, Giovanni, Blandino, Giovanni, Bagnato, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816119/
https://www.ncbi.nlm.nih.gov/pubmed/36604418
http://dx.doi.org/10.1038/s41419-022-05538-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816119/
https://www.ncbi.nlm.nih.gov/pubmed/36604418
http://dx.doi.org/10.1038/s41419-022-05538-6

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