Membrane-bound IL-2 improves the expansion, survival, and phenotype of CAR Tregs and confers resistance to calcineurin inhibitors

BACKGROUND: Regulatory T cells (Tregs) play an important role in the maintenance of immune homeostasis and the establishment of immune tolerance. Since Tregs do not secrete endogenous IL-2, they are especially dependent on external IL-2. IL-2 deficiency leads to lower Treg numbers, instability of th...

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Detalles Bibliográficos
Autores principales: Kremer, Jakob, Henschel, Pierre, Simon, Daniel, Riet, Tobias, Falk, Christine, Hardtke-Wolenski, Matthias, Wedemeyer, Heiner, Noyan, Fatih, Jaeckel, Elmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816406/
https://www.ncbi.nlm.nih.gov/pubmed/36618378
http://dx.doi.org/10.3389/fimmu.2022.1005582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816406/
https://www.ncbi.nlm.nih.gov/pubmed/36618378
http://dx.doi.org/10.3389/fimmu.2022.1005582

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