Cargando…
Research of storable and ready-to-use artificial red blood cells (hemoglobin vesicles) for emergency medicine and other clinical applications
Hemoglobin (Hb) is the most abundant protein in blood, with concentration of about 12–15 g/dl. The highly concentrated Hb solution (35 g/dl) is compartmentalized in red blood cells (RBCs). Once Hb is released from RBCs by hemolysis during blood circulation, it induces renal and cardiovascular toxici...
Autores principales: | Sakai, Hiromi, Kure, Tomoko, Taguchi, Kazuaki, Azuma, Hiroshi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816666/ https://www.ncbi.nlm.nih.gov/pubmed/36619343 http://dx.doi.org/10.3389/fmedt.2022.1048951 |
Ejemplares similares
-
First-in-human phase 1 trial of hemoglobin vesicles as artificial red blood cells developed for use as a transfusion alternative
por: Azuma, Hiroshi, et al.
Publicado: (2022) -
Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles
por: Tokuno, Masahiro, et al.
Publicado: (2020) -
Long-Term Stored Hemoglobin-Vesicles, a Cellular Type of Hemoglobin-Based Oxygen Carrier, Has Resuscitative Effects Comparable to That for Fresh Red Blood Cells in a Rat Model with Massive Hemorrhage without Post-Transfusion Lung Injury
por: Tokuno, Masahiro, et al.
Publicado: (2016) -
Overview of Potential Clinical Applications of Hemoglobin Vesicles (HbV) as Artificial Red Cells, Evidenced by Preclinical Studies of the Academic Research Consortium
por: Sakai, Hiromi
Publicado: (2017) -
Oxidation reactions of cellular and acellular hemoglobins: Implications for human health
por: Alayash, Abdu I.
Publicado: (2022)