Association of CYP2D6 genotype predicted phenotypes with oxycodone requirements and side effects in children undergoing surgery

BACKGROUND: Oxycodone is a commonly used oral opioid in children for treating postoperative pain. Highly polymorphic gene CYP2D6 metabolizes oxycodone into its more potent metabolite, oxymorphone. We hypothesized that altered activity due to CYP2D6 polymorphisms will influence oxycodone requirements...

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Detalles Bibliográficos
Autores principales: Merchant, Soroush, Prows, Cynthia A., Yang, Fang, Ding, Lili, MacDonald, Jacob, Zhang, Xue, Sadhasivam, Senthilkumar, Garcia, Victor, Sturm, Peter, Chidambaran, Vidya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816853/
https://www.ncbi.nlm.nih.gov/pubmed/36618804
http://dx.doi.org/10.21037/atm-2022-58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816853/
https://www.ncbi.nlm.nih.gov/pubmed/36618804
http://dx.doi.org/10.21037/atm-2022-58

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