Somatic variant detection from multi-sampled genomic sequencing data of tumor specimens using the ith.Variant pipeline

A common technique for uncovering intra-tumor genomic heterogeneity (ITH) is variant detection. However, it can be challenging to reliably characterize ITH given uneven sample quality (e.g., depth of coverage, tumor purity, and subclonality). We describe a protocol for calling point mutations and co...

Descripción completa

Detalles Bibliográficos
Autores principales: Maeser, Nicole, Khan, Aziz, Sun, Ruping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816983/
https://www.ncbi.nlm.nih.gov/pubmed/36586123
http://dx.doi.org/10.1016/j.xpro.2022.101927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816983/
https://www.ncbi.nlm.nih.gov/pubmed/36586123
http://dx.doi.org/10.1016/j.xpro.2022.101927

Ejemplares similares