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Somatic variant detection from multi-sampled genomic sequencing data of tumor specimens using the ith.Variant pipeline
A common technique for uncovering intra-tumor genomic heterogeneity (ITH) is variant detection. However, it can be challenging to reliably characterize ITH given uneven sample quality (e.g., depth of coverage, tumor purity, and subclonality). We describe a protocol for calling point mutations and co...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9816983/ https://www.ncbi.nlm.nih.gov/pubmed/36586123 http://dx.doi.org/10.1016/j.xpro.2022.101927 |