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Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression

BACKGROUND: N4-acetylcytidine (ac4C), a widespread modification in human mRNAs that is catalyzed by the N-acetyltransferase 10 (NAT10) enzyme, plays an important role in promoting mRNA stability and translation. However, the biological functions and regulatory mechanisms of NAT10-mediated ac4C were...

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Detalles Bibliográficos
Autores principales: Deng, Min, Zhang, Long, Zheng, Wenying, Chen, Jiale, Du, Nan, Li, Meiqi, Chen, Weiqing, Huang, Yonghong, Zeng, Ning, Song, Yuanbin, Chen, Yongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817303/
https://www.ncbi.nlm.nih.gov/pubmed/36609449
http://dx.doi.org/10.1186/s13046-022-02586-w