Cargando…
Comparative Proteomic and Transcriptomic Analysis of the Impact of Androgen Stimulation and Darolutamide Inhibition
SIMPLE SUMMARY: Mass spectrometry-based proteomic analysis of the VCaP prostate cancer cells treated with androgen and the androgen receptor (AR) signaling inhibitor darolutamide revealed a generally good agreement with transcriptomic responses. In some cases, however, the magnitude of changes induc...
Autores principales: | Nevedomskaya, Ekaterina, Sugawara, Tatsuo, Baumgart, Simon J., Lesche, Ralf, Hahne, Hannes, Mumberg, Dominik, Haendler, Bernard |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817687/ https://www.ncbi.nlm.nih.gov/pubmed/36611998 http://dx.doi.org/10.3390/cancers15010002 |
Ejemplares similares
-
Darolutamide antagonizes androgen signaling by blocking enhancer and super‐enhancer activation
por: Baumgart, Simon J., et al.
Publicado: (2020) -
Darolutamide is a potent androgen receptor antagonist with strong efficacy in prostate cancer models
por: Sugawara, Tatsuo, et al.
Publicado: (2019) -
Recent Advances in Prostate Cancer Treatment and Drug Discovery
por: Nevedomskaya, Ekaterina, et al.
Publicado: (2018) -
Dysregulated Transcriptional Control in Prostate Cancer
por: Baumgart, Simon J., et al.
Publicado: (2019) -
Darolutamide Potentiates the Antitumor Efficacy of a PSMA-targeted Thorium-227 Conjugate by a Dual Mode of Action in Prostate Cancer Models
por: Hammer, Stefanie, et al.
Publicado: (2021)