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The FDA-Approved Drug Pyrvinium Selectively Targets ER(+) Breast Cancer Cells with High INPP4B Expression

SIMPLE SUMMARY: Wnt/β-catenin signaling is hyperactivated in many human cancers including up to 50% of breast cancers. Although there has been significant progress in developing therapeutics that suppress Wnt/β-catenin signaling, particularly in colon cancer, the repurposing of FDA-approved therapeu...

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Detalles Bibliográficos
Autores principales: Rodgers, Samuel J., Ooms, Lisa M., Mitchell, Christina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817693/
https://www.ncbi.nlm.nih.gov/pubmed/36612130
http://dx.doi.org/10.3390/cancers15010135