Epigenetic Insights on PARP-1 Activity in Cancer Therapy

SIMPLE SUMMARY: PARP-1 and poly(ADP-ribosyl)ation control gene expression, DNA repair pathways, and genomic stability in multiple ways, such as affecting chromatin remodelling. This review article summarises how PARP-1 activity directly modifies histone proteins and the enzymes involved in DNA/histo...

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Detalles Bibliográficos
Autores principales: Pinton, Giulia, Boumya, Sara, Ciriolo, Maria Rosa, Ciccarone, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817704/
https://www.ncbi.nlm.nih.gov/pubmed/36612003
http://dx.doi.org/10.3390/cancers15010006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817704/
https://www.ncbi.nlm.nih.gov/pubmed/36612003
http://dx.doi.org/10.3390/cancers15010006

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