p90RSK Regulates p53 Pathway by MDM2 Phosphorylation in Thyroid Tumors

SIMPLE SUMMARY: p90RSK is a downstream effector protein of the MAPK pathway. In many human cancers, the MAPK pathway is constitutively activated due to oncogenic mutations of its components. Consequently, p90RSK is hyperactive and capable of hyper phosphorylating substrates involved in tumorigenesis...

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Detalles Bibliográficos
Autores principales: Maietta, Immacolata, Del Peschio, Francesca, Buonocore, Preziosa, Viscusi, Eleonora, Laudati, Stefano, Iannaci, Giuseppe, Minopoli, Michele, Motti, Maria Letizia, De Falco, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817759/
https://www.ncbi.nlm.nih.gov/pubmed/36612117
http://dx.doi.org/10.3390/cancers15010121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817759/
https://www.ncbi.nlm.nih.gov/pubmed/36612117
http://dx.doi.org/10.3390/cancers15010121

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