TP-0903 Is Active in Preclinical Models of Acute Myeloid Leukemia with TP53 Mutation/Deletion

SIMPLE SUMMARY: Acute myeloid leukemia (AML) with mutations in the tumor suppressor gene TP53 is rapidly lethal for most patients. Here, we investigated the preclinical activity of TP-0903, a multikinase inhibitor that inhibits kinases with potential synthetical lethality in TP53 mutant AML. TP-0903...

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Detalles Bibliográficos
Autores principales: Eisenmann, Eric D., Stromatt, Jack C., Fobare, Sydney, Huang, Kevin M., Buelow, Daelynn R., Orwick, Shelley, Jeon, Jae Yoon, Weber, Robert H., Larsen, Bill, Mims, Alice S., Hertlein, Erin, Byrd, John C., Baker, Sharyn D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817780/
https://www.ncbi.nlm.nih.gov/pubmed/36612026
http://dx.doi.org/10.3390/cancers15010029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817780/
https://www.ncbi.nlm.nih.gov/pubmed/36612026
http://dx.doi.org/10.3390/cancers15010029

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