Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer

SIMPLE SUMMARY: We targeted abnormalities in lipid metabolism of liver cancer cells and showed that tumoral addiction to lipids can be potentially overridden by available drugs. Anti-PCSK9 alone or in combination with statin treatment can live up to this challenge and disrupt the process of oncogene...

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Detalles Bibliográficos
Autores principales: Alannan, Malak, Trézéguet, Véronique, Amoêdo, Nivea Dias, Rossignol, Rodrigue, Mahfouf, Walid, Rezvani, Hamid Reza, Dittrich-Domergue, Franziska, Moreau, Patrick, Lacomme, Sabrina, Gontier, Etienne, Grosset, Christophe F., Badran, Bassam, Fayyad-Kazan, Hussein, Merched, Aksam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817797/
https://www.ncbi.nlm.nih.gov/pubmed/36612001
http://dx.doi.org/10.3390/cancers15010003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817797/
https://www.ncbi.nlm.nih.gov/pubmed/36612001
http://dx.doi.org/10.3390/cancers15010003

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