Cargando…

Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer

SIMPLE SUMMARY: We targeted abnormalities in lipid metabolism of liver cancer cells and showed that tumoral addiction to lipids can be potentially overridden by available drugs. Anti-PCSK9 alone or in combination with statin treatment can live up to this challenge and disrupt the process of oncogene...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alannan, Malak, Trézéguet, Véronique, Amoêdo, Nivea Dias, Rossignol, Rodrigue, Mahfouf, Walid, Rezvani, Hamid Reza, Dittrich-Domergue, Franziska, Moreau, Patrick, Lacomme, Sabrina, Gontier, Etienne, Grosset, Christophe F., Badran, Bassam, Fayyad-Kazan, Hussein, Merched, Aksam J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817797/ https://www.ncbi.nlm.nih.gov/pubmed/36612001 http://dx.doi.org/10.3390/cancers15010003

Ejemplares similares

Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by Ferroptosis
por: Alannan, Malak, et al.
Publicado: (2022)

PCSK9 in Liver Cancers at the Crossroads between Lipid Metabolism and Immunity
por: Alannan, Malak, et al.
Publicado: (2022)

Immuno-Metabolic Modulation of Liver Oncogenesis by the Tryptophan Metabolism
por: Trézéguet, Véronique, et al.
Publicado: (2021)

Xeroderma Pigmentosum C (XPC) Mutations in Primary Fibroblasts Impair Base Excision Repair Pathway and Increase Oxidative DNA Damage
por: Fayyad, Nour, et al.
Publicado: (2020)

Proteomic Study of Low-Birth-Weight Nephropathy in Rats
por: Imasawa, Toshiyuki, et al.
Publicado: (2021)

Study of the microRNA expression profile of foreskin derived mesenchymal stromal cells following inflammation priming
por: Fayyad-Kazan, Hussein, et al.
Publicado: (2017)

Genetic variations in HMGCR and PCSK9 and kidney function: a Mendelian randomization study
por: Park, Sehoon, et al.
Publicado: (2023)

Evaluation of the Osteogenic Potential of Different Scaffolds Embedded with Human Stem Cells Originated from Schneiderian Membrane: An In Vitro Study
por: Bou Assaf, Rita, et al.
Publicado: (2019)

High-throughput synthetic rescue for exhaustive characterization of suppressor mutations in human genes
por: Kobaisi, Farah, et al.
Publicado: (2020)

Isoconazole and Clemizole Hydrochloride Partially Reverse the Xeroderma Pigmentosum C Phenotype
por: Kobaisi, Farah, et al.
Publicado: (2021)

Circulating miRNAs: Potential diagnostic role for coronavirus disease 2019 (COVID-19)
por: Fayyad-Kazan, Mohammad, et al.
Publicado: (2021)

Chemical Composition and Biological Activities of Lebanese Pentapera Plant
por: Kallassy, Hany, et al.
Publicado: (2019)

Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries
por: Rosoff, Daniel B., et al.
Publicado: (2023)

Chemical Composition and Antioxidant, Anti-Inflammatory, and Antiproliferative Activities of Lebanese Ephedra Campylopoda Plant
por: Kallassy, Hany, et al.
Publicado: (2017)

Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers
por: Nasrallah, A., et al.
Publicado: (2021)

Anti-HMGCR Myopathy
por: Mohassel, Payam, et al.
Publicado: (2018)

Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study
por: Benn, Marianne, et al.
Publicado: (2017)

Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study
Publicado: (2017)

Chemical Composition, Antioxidant, Anti-Inflammatory, and Antiproliferative Activities of the Plant Lebanese Crataegus Azarolus L
por: Kallassy, Hany, et al.
Publicado: (2017)

Therapeutic Advantage of Targeting PRMT5 in Combination with Chemotherapies or EGFR/HER2 Inhibitors in Triple-Negative Breast Cancers
por: Dakroub, Rayan, et al.
Publicado: (2023)

Signaling Pathways, Chemical and Biological Modulators of Nucleotide Excision Repair: The Faithful Shield against UV Genotoxicity
por: Kobaisi, F., et al.
Publicado: (2019)

Circulating miR-150 and miR-342 in plasma are novel potential biomarkers for acute myeloid leukemia
por: Fayyad-Kazan, Hussein, et al.
Publicado: (2013)

Amino Acid Conjugates of 2-Mercaptobenzimidazole Ameliorates High-Fat Diet-Induced Hyperlipidemia in Rats via Attenuation of HMGCR, APOB, and PCSK9
por: Shabbir, Ramla, et al.
Publicado: (2022)

PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction
por: Da Dalt, Lorenzo, et al.
Publicado: (2021)

Tracking cellular and molecular changes in a species-specific manner during experimental tumor progression in vivo
por: Indersie, Emilie, et al.
Publicado: (2018)

Redox mechanism of levobupivacaine cytostatic effect on human prostate cancer cells
por: Jose, Caroline, et al.
Publicado: (2018)

Therapeutic targets of hypercholesterolemia: HMGCR and LDLR
por: Ma, Shizhan, et al.
Publicado: (2019)

Anti-HMGCR antibodies in systemic sclerosis
por: Hudson, Marie, et al.
Publicado: (2016)

Healing of Bone Defects in Pig's Femur Using Mesenchymal Cells Originated from the Sinus Membrane with Different Scaffolds
por: Bou Assaf, Rita, et al.
Publicado: (2019)

Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F
por: Esteves, Pauline, et al.
Publicado: (2019)

In Vitro Influence of Prophylaxis Cleaning on Enamel Remineralization with Casein Phosphopeptide-Amorphous Calcium Phosphate
por: Zeitouny, Mona, et al.
Publicado: (2020)

Myopathy with anti-HMGCR antibodies: Perimysium and myofiber pathology
por: Alshehri, Ali, et al.
Publicado: (2015)

Anti-HMGCR Specificity of HALIP: A Confirmatory Study
por: Baucells, Andrés, et al.
Publicado: (2020)

A microRNA profile of human CD8(+) regulatory T cells and characterization of the effects of microRNAs on Treg cell-associated genes
por: Jebbawi, Fadi, et al.
Publicado: (2014)

Identification and Evaluation of New Immunoregulatory Genes in Mesenchymal Stromal Cells of Different Origins: Comparison of Normal and Inflammatory Conditions
por: Fayyad-Kazan, Mohammad, et al.
Publicado: (2017)

Clinical and Radiological Features of Korean Patients With Anti-HMGCR Myopathy
por: Oh, Eun Kyoung, et al.
Publicado: (2023)

Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats
por: Jin, Shu-wen, et al.
Publicado: (2023)

Data on nitric oxide production by human bone marrow-derived mesenchymal stromal cells
por: Najar, Mehdi, et al.
Publicado: (2016)

Relationship Between the Remaining Dentin Thickness and Coronal Pulp Status of Decayed Primary Molars
por: Berbari, Roula, et al.
Publicado: (2017)

Global MicroRNA Expression Profiling Identifies MiR-210 Associated with Tumor Proliferation, Invasion and Poor Clinical Outcome in Breast Cancer
por: Rothé, Françoise, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_o9bqtaie19dnnj2ak6b1t6vq19