The Ginsenoside Compound K Suppresses Stem-Cell-like Properties and Colorectal Cancer Metastasis by Targeting Hypoxia-Driven Nur77-Akt Feed-Forward Signaling

SIMPLE SUMMARY: Compound K (CK) is the major functional ginsenoside metabolite derived from ginseng, one of the most popular traditional Chinese medicines, with unknown mechanistic targets. We describe here that CK directly binds and modulates Nur77 phosphorylation to deplete cancer stem-cell-like c...

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Detalles Bibliográficos
Autores principales: Zhang, Minda, Shi, Zeyu, Zhang, Shuaishuai, Li, Xudan, To, Sally Kit Yan, Peng, Yijia, Liu, Jie, Chen, Siming, Hu, Hongyu, Wong, Alice Sze Tsai, Zeng, Jin-Zhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817892/
https://www.ncbi.nlm.nih.gov/pubmed/36612021
http://dx.doi.org/10.3390/cancers15010024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817892/
https://www.ncbi.nlm.nih.gov/pubmed/36612021
http://dx.doi.org/10.3390/cancers15010024

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