Identification of Thiazolo[5,4-b]pyridine Derivatives as c-KIT Inhibitors for Overcoming Imatinib Resistance

SIMPLE SUMMARY: c-KIT has been regarded as a promising therapeutic target against gastrointestinal stromal tumor (GIST). Overcoming drug resistance of c-KIT inhibitors including imatinib is required. We designed and synthesized novel thiazolo[5,4-b]pyridine derivatives and performed structure-activi...

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Detalles Bibliográficos
Autores principales: Nam, Yunju, Kim, Chan, Han, Junghee, Ryu, SeongShick, Cho, Hanna, Song, Chiman, Kim, Nam Doo, Kim, Namkyoung, Sim, Taebo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817970/
https://www.ncbi.nlm.nih.gov/pubmed/36612139
http://dx.doi.org/10.3390/cancers15010143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817970/
https://www.ncbi.nlm.nih.gov/pubmed/36612139
http://dx.doi.org/10.3390/cancers15010143

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