YO2 Induces Melanoma Cell Apoptosis through p53-Mediated LRP1 Downregulation

SIMPLE SUMMARY: We found that induction of tumor suppressor p53 in melanoma cells suppressed tumor growth by targeting LRP1 expression. LRP1 downregulation was achieved by the micro RNAs miR103/107. We identify the small molecule YO-2 as an inducer of tumor suppressor p53. We propose that YO-2, comb...

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Detalles Bibliográficos
Autores principales: Salama, Yousef, Takahashi, Satoshi, Tsuda, Yuko, Okada, Yoshio, Hattori, Koichi, Heissig, Beate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818169/
https://www.ncbi.nlm.nih.gov/pubmed/36612285
http://dx.doi.org/10.3390/cancers15010288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818169/
https://www.ncbi.nlm.nih.gov/pubmed/36612285
http://dx.doi.org/10.3390/cancers15010288

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