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YO2 Induces Melanoma Cell Apoptosis through p53-Mediated LRP1 Downregulation
SIMPLE SUMMARY: We found that induction of tumor suppressor p53 in melanoma cells suppressed tumor growth by targeting LRP1 expression. LRP1 downregulation was achieved by the micro RNAs miR103/107. We identify the small molecule YO-2 as an inducer of tumor suppressor p53. We propose that YO-2, comb...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818169/ https://www.ncbi.nlm.nih.gov/pubmed/36612285 http://dx.doi.org/10.3390/cancers15010288 |