CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2

Human Perrault syndrome (PRLTS) is autosomal, recessively inherited, and characterized by ovarian insufficiency with hearing loss. Among the genetic causes are mutations of matrix peptidase CLPP, which trigger additional azoospermia. Here, we analyzed the impact of CLPP deficiency on male mouse meio...

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Detalles Bibliográficos
Autores principales: Key, Jana, Gispert, Suzana, Koornneef, Lieke, Sleddens-Linkels, Esther, Kohli, Aneesha, Torres-Odio, Sylvia, Koepf, Gabriele, Amr, Shady, Reichlmeir, Marina, Harter, Patrick N., West, Andrew Phillip, Münch, Christian, Baarends, Willy M., Auburger, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818230/
https://www.ncbi.nlm.nih.gov/pubmed/36611846
http://dx.doi.org/10.3390/cells12010052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818230/
https://www.ncbi.nlm.nih.gov/pubmed/36611846
http://dx.doi.org/10.3390/cells12010052

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