Cargando…

PNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL

The single nucleotide polymorphism I148M of the lipase patatin-like phospholipase domain containing 3 (PNPLA3) is associated with an unfavorable prognosis in alcoholic and non-alcoholic steatohepatitis (ASH, NASH), with progression to liver cirrhosis and development of hepatocellular carcinoma. In t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Witzel, Hagen Roland, Schwittai, Inga Maria Gertrud, Hartmann, Nils, Mueller, Sebastian, Schattenberg, Jörn M., Gong, Xue-Min, Backs, Johannes, Schirmacher, Peter, Schuppan, Detlef, Roth, Wilfried, Straub, Beate Katharina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818421/ https://www.ncbi.nlm.nih.gov/pubmed/36611868 http://dx.doi.org/10.3390/cells12010073

Ejemplares similares

Lipid Droplet-Associated Proteins Perilipin 1 and 2: Molecular Markers of Steatosis and Microvesicular Steatotic Foci in Chronic Hepatitis C
por: Schelbert, Selina, et al.
Publicado: (2022)

Human Frame Shift Mutations Affecting the Carboxyl Terminus of Perilipin Increase Lipolysis by Failing to Sequester the Adipose Triglyceride Lipase (ATGL) Coactivator AB-hydrolase-containing 5 (ABHD5)
por: Gandotra, Sheetal, et al.
Publicado: (2011)

The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy
por: Zhang, Gaojian, et al.
Publicado: (2022)

Higher Levels of ATGL Are Associated with Exercise-Induced Enhancement of Lipolysis in Rat Epididymal Adipocytes
por: Ogasawara, Junetsu, et al.
Publicado: (2012)

OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis
por: Wang, Tianming, et al.
Publicado: (2020)

Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue
por: Schreiber, Renate, et al.
Publicado: (2017)

Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
por: Smagris, Eriks, et al.
Publicado: (2015)

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
por: Khan, Salmaan Ahmed, et al.
Publicado: (2015)

Nicotinamide mononucleotide induces lipolysis by regulating ATGL expression via the SIRT1-AMPK axis in adipocytes
por: Imi, Yukiko, et al.
Publicado: (2023)

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
por: Lindén, Daniel, et al.
Publicado: (2019)

Cytokine-Mediated STAT3 Transcription Supports ATGL/CGI-58-Dependent Adipocyte Lipolysis in Cancer Cachexia
por: Gandhi, Aakash Y., et al.
Publicado: (2022)

Perilipin2 plays a positive role in adipocytes during lipolysis by escaping proteasomal degradation
por: Takahashi, Yu, et al.
Publicado: (2016)

Adipocyte lipolysis affects Perilipin 5 and cristae organization at the cardiac lipid droplet-mitochondrial interface
por: Varghese, Mita, et al.
Publicado: (2019)

Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation
por: Liu, Xirui, et al.
Publicado: (2018)

Amidation-Modified Apelin-13 Regulates PPARγ and Perilipin to Inhibit Adipogenic Differentiation and Promote Lipolysis
por: Wang, Sha, et al.
Publicado: (2021)

Perilipin 1 Deficiency Prompts Lipolysis in Lipid Droplets and Aggravates the Pathogenesis of Persistent Immune Activation in Drosophila
por: Wang, Lei, et al.
Publicado: (2023)

An Epistatic Interaction between Pnpla2 and Lipe Reveals New Pathways of Adipose Tissue Lipolysis
por: Zhang, Xiao, et al.
Publicado: (2019)

PNPLA3 I148M Polymorphism, Clinical Presentation, and Survival in Patients with Hepatocellular Carcinoma
por: Valenti, Luca, et al.
Publicado: (2013)

The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels
por: Stojkovic, Ivana A., et al.
Publicado: (2014)

Differential Phosphorylation of Perilipin 1A at the Initiation of Lipolysis Revealed by Novel Monoclonal Antibodies and High Content Analysis
por: McDonough, Patrick M., et al.
Publicado: (2013)

Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis
por: Kuo, Taiyi, et al.
Publicado: (2017)

Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice
por: Kolleritsch, Stephanie, et al.
Publicado: (2020)

A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice
por: Attané, Camille, et al.
Publicado: (2016)

Palmitate induces fat accumulation via repressing FoxO1-mediated ATGL-dependent lipolysis in HepG2 hepatocytes
por: Zhao, Naiqian, et al.
Publicado: (2021)

A Common Variant of PNPLA3 (p.I148M) Is Not Associated with Alcoholic Chronic Pancreatitis
por: Rosendahl, Jonas, et al.
Publicado: (2012)

PNPLA3 I148M associations with liver carcinogenesis in Japanese chronic hepatitis C patients
por: Nakaoka, Kazunori, et al.
Publicado: (2015)

Erratum to: The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels
por: Stojkovic, Ivana A., et al.
Publicado: (2016)

PNPLA3-I148M: a problem of plenty in non-alcoholic fatty liver disease
por: BasuRay, Soumik
Publicado: (2019)

PNPLA3-I148M Variant Promotes the Progression of Liver Fibrosis by Inducing Mitochondrial Dysfunction
por: Gou, Yusong, et al.
Publicado: (2023)

Corrigendum to: Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice
Publicado: (2019)

Distinct roles for α-β hydrolase domain 5 (ABHD5/CGI-58) and adipose triglyceride lipase (ATGL/PNPLA2) in lipid metabolism and signaling
por: Lord, Caleb C., et al.
Publicado: (2012)

Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection
por: Tang, Mengling, et al.
Publicado: (2020)

The i148m Pnpla3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls
por: Valenti, Luca, et al.
Publicado: (2012)

PNPLA3 I148M Up-Regulates Hedgehog and Yap Signaling in Human Hepatic Stellate Cells
por: Bruschi, Francesca Virginia, et al.
Publicado: (2020)

Recent Advances on the Role of ATGL in Cancer
por: Zhang, Renshuai, et al.
Publicado: (2022)

Measurement of ATGL activity using adiposomes
por: Ma, Xuejing, et al.
Publicado: (2023)

Transforming Growth Factor-β Activated Kinase 1 (Tak1) Is Activated in Hepatocellular Carcinoma, Mediates Tumor Progression, and Predicts Unfavorable Outcome
por: Ridder, Dirk Andreas, et al.
Publicado: (2022)

Okadaic Acid, a Bioactive Fatty Acid from Halichondria okadai, Stimulates Lipolysis in Rat Adipocytes: The Pivotal Role of Perilipin Translocation
por: Chang, Nen-Chung, et al.
Publicado: (2013)

Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function
por: Gallardo-Montejano, Violeta I., et al.
Publicado: (2016)

Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease
por: Huang, Yongcheng, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_olg3g2gd1q0pi4td356ceoilcf