Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by Ferroptosis

Deregulated lipid metabolism is a common feature of liver cancers needed to sustain tumor cell growth and survival. We aim at taking advantage of this vulnerability and rewiring the oncogenic metabolic hub by targeting the key metabolic player pro-protein convertase subtilisin/kexin type 9 (PCSK9)....

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Detalles Bibliográficos
Autores principales: Alannan, Malak, Fatrouni, Hala, Trézéguet, Véronique, Dittrich-Domergue, Franziska, Moreau, Patrick, Siegfried, Géraldine, Liet, Benjamin, Khatib, Abdel-Majid, Grosset, Christophe F., Badran, Bassam, Fayyad-Kazan, Hussein, Merched, Aksam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818499/
https://www.ncbi.nlm.nih.gov/pubmed/36611859
http://dx.doi.org/10.3390/cells12010062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818499/
https://www.ncbi.nlm.nih.gov/pubmed/36611859
http://dx.doi.org/10.3390/cells12010062

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