Cargando…

Multiformin-Type Azaphilones Prevent SARS-CoV-2 Binding to ACE2 Receptor

Protein microarray screenings identified fungal natural products from the azaphilone family as potent inhibitors of SARS-CoV-2 spike protein binding to host ACE2 receptors. Cohaerin F, as the most potent substance from the cohaerin group, led to more than 50% less binding of ACE2 and SARS-CoV-2 spik...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jansen-Olliges, Linda, Chatterjee, Shambhabi, Jia, Lili, Stahl, Frank, Bär, Christian, Stadler, Marc, Surup, Frank, Zeilinger, Carsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818685/ https://www.ncbi.nlm.nih.gov/pubmed/36611877 http://dx.doi.org/10.3390/cells12010083

Ejemplares similares

Analysis of SARS-CoV-2 spike RBD binding to ACE2 and its inhibition by fungal cohaerin C using surface enhanced Raman spectroscopy
por: Wetzel, Christoph, et al.
Publicado: (2023)

Hybridorubrins A–D: Azaphilone Heterodimers from Stromata of Hypoxylon fragiforme and Insights into the Biosynthetic Machinery for Azaphilone Diversification
por: Becker, Kevin, et al.
Publicado: (2020)

MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes
por: Lu, Dongchao, et al.
Publicado: (2020)

Identification of a Thyroid Hormone Binding Site in Hsp90 with Implications for Its Interaction with Thyroid Hormone Receptor Beta
por: Fan, Lu, et al.
Publicado: (2022)

Recent Findings in Azaphilone Pigments
por: Pimenta, Lúcia P. S., et al.
Publicado: (2021)

New azaphilones from Aspergillus neoglaber
por: Isbrandt, Thomas, et al.
Publicado: (2020)

Recent advances in the chemistry and biology of azaphilones
por: Chen, Chunmei, et al.
Publicado: (2020)

Litoralimycins A and B, New Cytotoxic Thiopeptides from Streptomonospora sp. M2
por: Khodamoradi, Shadi, et al.
Publicado: (2020)

Azaphilones from the Red Sea Fungus Aspergillus falconensis
por: El-Kashef, Dina H., et al.
Publicado: (2020)

Core Steps to the Azaphilone Family of Fungal Natural Products
por: Williams, Katherine, et al.
Publicado: (2021)

Orange, red, yellow: biosynthesis of azaphilone pigments in Monascus fungi
por: Chen, Wanping, et al.
Publicado: (2017)

A Novel Azaphilone Muyophilone A From the Endophytic Fungus Muyocopron laterale 0307-2
por: Yuan, Chao, et al.
Publicado: (2021)

Silphiperfolene-Type Terpenoids and Other Metabolites from Cultures of the Tropical Ascomycete Hypoxylon rickii (Xylariaceae)
por: Surup, Frank, et al.
Publicado: (2015)

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro
por: Kaur, Kawaljit, et al.
Publicado: (2017)

New Azaphilones from Nigrospora oryzae Co-Cultured with Beauveria bassiana
por: Zhang, Zhuo-Xi, et al.
Publicado: (2018)

Muyocopronones A and B: azaphilones from the endophytic fungus Muyocopron laterale
por: Nakashima, Ken-ichi, et al.
Publicado: (2020)

Elsinopirins A–D, Decalin Polyketides from the Ascomycete Elsinoё pyri
por: Surup, Frank, et al.
Publicado: (2018)

Thielavialides A–E, Nor-Spiro-azaphilones, and a Bis-spiro-azaphilone from Thielavia sp. PA0001, An Endophytic Fungus Isolated from Aeroponically Grown Physalis alkekengi†
por: Wijeratne, E. M. Kithsiri, et al.
Publicado: (2014)

Azaphilones from the Marine Sponge-Derived Fungus Penicillium sclerotiorum OUCMDZ-3839
por: Jia, Qian, et al.
Publicado: (2019)

Anti-Inflammatory Azaphilones from the Edible Alga-Derived Fungus Penicillium sclerotiorum
por: Wang, Hui-Chun, et al.
Publicado: (2021)

Phytotoxic Azaphilones From the Mangrove-Derived Fungus Penicillium sclerotiorum HY5
por: Wang, Wei, et al.
Publicado: (2022)

A New Azaphilone, Kasanosin C, from an Endophytic Talaromyces sp. T1BF
por: Li, Liang-Qun, et al.
Publicado: (2010)

New Cytotoxic Azaphilones from Monascus purpureus-Fermented Rice (Red Yeast Rice)
por: Li, Jin-Jie, et al.
Publicado: (2010)

Binding of SARS-COV-2 (COVID-19) and SARS-COV to human ACE2: Identifying binding sites and consequences on ACE2 stiffness
por: Faisal, H.M. Nasrullah, et al.
Publicado: (2021)

Pro-angiogenic New Chloro-Azaphilone Derivatives From the Hadal Trench-Derived Fungus Chaetomium globosum YP-106
por: Fan, Yaqin, et al.
Publicado: (2022)

Angiotensin Converting Enzyme (ACE) and ACE2 Bind Integrins and ACE2 Regulates Integrin Signalling
por: Clarke, Nicola E., et al.
Publicado: (2012)

Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea
por: Sandargo, Birthe, et al.
Publicado: (2018)

Amycolatomycins A and B, Cyclic Hexapeptides Isolated from an Amycolatopsis sp. 195334CR
por: Primahana, Gian, et al.
Publicado: (2021)

Seven New Cytotoxic and Antimicrobial Xanthoquinodins from Jugulospora vestita
por: Shao, Lulu, et al.
Publicado: (2020)

Morinagadepsin, a Depsipeptide from the Fungus Morinagamyces vermicularis gen. et comb. nov.
por: Harms, Karen, et al.
Publicado: (2021)

Azaphilones produced by Penicillium maximae with their cell death-inducing activity on Adriamycin-treated cancer cell
por: Matsumoto, Takahiro, et al.
Publicado: (2023)

Five Tetramic Acid Derivatives Isolated from the Iranian Fungus Colpoma quercinum CCTU A372
por: Primahana, Gian, et al.
Publicado: (2021)

Calamene-Type Sesqui-, Mero-, and Bis-sesquiterpenoids from Cultures of Heimiomyces sp., a Basidiomycete Collected in Africa
por: Pfütze, Sebastian, et al.
Publicado: (2023)

Heimionones A–E, New Sesquiterpenoids Produced by Heimiomyces sp., a Basidiomycete Collected in Africa
por: Pfütze, Sebastian, et al.
Publicado: (2023)

New Azaphilones, Seco-Chaetomugilins A and D, Produced by a Marine-Fish-Derived Chaetomium globosum
por: Yamada, Takeshi, et al.
Publicado: (2009)

Penicilazaphilone C, a New Azaphilone, Induces Apoptosis in Gastric Cancer by Blocking the Notch Signaling Pathway
por: Wang, Ming, et al.
Publicado: (2020)

Combining OSMAC, metabolomic and genomic methods for the production and annotation of halogenated azaphilones and ilicicolins in termite symbiotic fungi
por: Hebra, Téo, et al.
Publicado: (2022)

Comparative docking studies to understand the binding affinity of nicotine with soluble ACE2 (sACE2)-SARS-CoV-2 complex over sACE2
por: C., Selvaa Kumar, et al.
Publicado: (2020)

Three New Derivatives of Zopfinol from Pseudorhypophila Mangenotii gen. et comb. nov.
por: Harms, Karen, et al.
Publicado: (2021)

Bioactive Compounds from an Endophytic Pezicula sp. Showing Antagonistic Effects against the Ash Dieback Pathogen
por: Demir, Özge, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_eunjdmh3lrh1br69dnbrgir2ja