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Advanced Maternal Age Differentially Affects Embryonic Tissues with the Most Severe Impact on the Developing Brain

Advanced maternal age (AMA) poses the single greatest risk to a successful pregnancy. Apart from the impact of AMA on oocyte fitness, aged female mice often display defects in normal placentation. Placental defects in turn are tightly correlated with brain and cardiovascular abnormalities. It theref...

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Detalles Bibliográficos
Autores principales: Kokorudz, Caroline, Radford, Bethany N., Dean, Wendy, Hemberger, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818809/
https://www.ncbi.nlm.nih.gov/pubmed/36611870
http://dx.doi.org/10.3390/cells12010076