Cargando…

Oral Squamous Cell Carcinoma Cells with Acquired Resistance to Erlotinib Are Sensitive to Anti-Cancer Effect of Quercetin via Pyruvate Kinase M2 (PKM2)

Oral squamous cell carcinoma (OSCC) frequently carries high epidermal growth factor receptor (EGFR) expression. Erlotinib, a small molecule tyrosine kinase inhibitor (TKI), is an effective inhibitor of EGFR activity; however, resistance to this drug can occur, limiting therapeutic outcomes. Therefor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chan, Chien-Yi, Hong, Shih-Cing, Chang, Chin-Ming, Chen, Yuan-Hong, Liao, Pin-Chen, Huang, Chun-Yin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818869/ https://www.ncbi.nlm.nih.gov/pubmed/36611972 http://dx.doi.org/10.3390/cells12010179

Ejemplares similares

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis
por: Bluemlein, Katharina, et al.
Publicado: (2011)

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis
por: Zahra, Kulsoom, et al.
Publicado: (2020)

Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin
por: Hossain, Abu Jubayer, et al.
Publicado: (2023)

β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the K(ATP) channel
por: Foster, Hannah R, et al.
Publicado: (2022)

Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis
por: Guo, Jianshuang, et al.
Publicado: (2019)

Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2)
por: James, Andrew D., et al.
Publicado: (2019)

Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro
por: Yuan, Sujuan, et al.
Publicado: (2016)

Pyruvate kinase M2 (PKM2) expression correlates with prognosis in solid cancers: a meta-analysis
por: Zhu, Haiyan, et al.
Publicado: (2016)

Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis
por: Wubben, Thomas J., et al.
Publicado: (2020)

Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis
por: Wubben, Thomas J., et al.
Publicado: (2023)

Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator
por: Filipp, Fabian V.
Publicado: (2013)

LNCAROD enhances hepatocellular carcinoma malignancy by activating glycolysis through induction of pyruvate kinase isoform PKM2
por: Jia, Guizhi, et al.
Publicado: (2021)

Inhibition of Proliferation, Migration, and Invasion by Knockdown of Pyruvate Kinase-M2 (PKM2) in Ovarian Cancer SKOV3 and OVCAR3 Cells
por: Miao, Yi, et al.
Publicado: (2016)

Effects of Pyruvate Kinase M2 (PKM2) Gene Deletion on Astrocyte-Specific Glycolysis and Global Cerebral Ischemia-Induced Neuronal Death
por: Kang, Beom-Seok, et al.
Publicado: (2023)

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers
por: Desai, Shruti, et al.
Publicado: (2013)

From Glucose to Lactate and Transiting Intermediates Through Mitochondria, Bypassing Pyruvate Kinase: Considerations for Cells Exhibiting Dimeric PKM2 or Otherwise Inhibited Kinase Activity
por: Chinopoulos, Christos
Publicado: (2020)

PKM2 Modulation in Head and Neck Squamous Cell Carcinoma
por: Boschert, Verena, et al.
Publicado: (2022)

Nuclear Pyruvate Kinase M2 (PKM2) Contributes to Phosphoserine Aminotransferase 1 (PSAT1)-Mediated Cell Migration in EGFR-Activated Lung Cancer Cells
por: Biyik-Sit, Rumeysa, et al.
Publicado: (2021)

Retraction Note: LNCAROD enhances hepatocellular carcinoma malignancy by activating glycolysis through induction of pyruvate kinase isoform PKM2
por: Jia, Guizhi, et al.
Publicado: (2023)

Pyruvate kinase M2 (PKM2) improve symptoms of post‐ischemic stroke depression by activating VEGF to mediate the MAPK/ERK pathway
por: Feng, Yun, et al.
Publicado: (2021)

miR-4417 Targets Tripartite Motif-Containing 35 (TRIM35) and Regulates Pyruvate Kinase Muscle 2 (PKM2) Phosphorylation to Promote Proliferation and Suppress Apoptosis in Hepatocellular Carcinoma Cells
por: Song, Lijie, et al.
Publicado: (2017)

PKM2 functions as a histone kinase
por: Lu, Zhimin
Publicado: (2012)

Proteomic Profiling of Mouse Brain Pyruvate Kinase Binding Proteins: A Hint for Moonlighting Functions of PKM1?
por: Buneeva, Olga, et al.
Publicado: (2023)

Pyruvate kinase M2 deregulation enhances the metastatic potential of tongue squamous cell carcinoma
por: Wang, Wei, et al.
Publicado: (2017)

Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling
por: Kejiou, Nevraj S, et al.
Publicado: (2023)

Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities
por: Xiong, Ping Yu, et al.
Publicado: (2019)

Protein kinase function of pyruvate kinase M2 and cancer
por: Chen, Xun, et al.
Publicado: (2020)

PKM2 and cancer: The function of PKM2 beyond glycolysis
por: DONG, GAOCHAO, et al.
Publicado: (2016)

High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway
por: Wang, Wei, et al.
Publicado: (2017)

Organ-Specific MicroRNAs (MIR122, 137, and 206) Contribute to Tissue Characteristics and Carcinogenesis by Regulating Pyruvate Kinase M1/2 (PKM) Expression
por: Taniguchi, Kohei, et al.
Publicado: (2018)

Pyruvate kinase M2 is a marker of poor prognosis in lung adenocarcinoma but not lung squamous cell carcinoma
por: Zhang, Junxia, et al.
Publicado: (2020)

Prognostic significance of pyruvate kinase M2 expression in esophageal squamous cell carcinoma and its meta-analysis
por: Zhang, Qiqi, et al.
Publicado: (2021)

BIMG-16. TRACKING TTFIELDS-INDUCED ALTERATIONS IN GLIOBLASTOMA METABOLISM WITH [18F]DASA-23, A NON-INVASIVE PROBE OF PYRUVATE KINASE M2 (PKM2)
por: Patel, Chirag, et al.
Publicado: (2021)

The mTOR Pathway Regulates PKM2 to Affect Glycolysis in Esophageal Squamous Cell Carcinoma
por: Xiaoyu, He, et al.
Publicado: (2018)

SUMOylation of HSP27 regulates PKM2 to promote esophageal squamous cell carcinoma progression
por: Zhang, Xiao, et al.
Publicado: (2020)

Metformin sensitizes lung cancer cells to treatment by the tyrosine kinase inhibitor erlotinib
por: Wang, Xiaofei, et al.
Publicado: (2017)

Transcription factor LHX9 (LIM Homeobox 9) enhances pyruvate kinase PKM2 activity to induce glycolytic metabolic reprogramming in cancer stem cells, promoting gastric cancer progression
por: Zhao, Hongying, et al.
Publicado: (2023)

Overexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression
por: Zheng, Bin, et al.
Publicado: (2018)

Efficacy of gefitinib or erlotinib in patients with squamous cell lung cancer
por: Song, Zhengbo, et al.
Publicado: (2013)

Squamous cell carcinomas of the skin responsive to erlotinib: 5 cases
por: Read, William L., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_juvm6cpf031eq25m63jfajngsf