Glutamine Produces Ammonium to Tune Lysosomal pH and Regulate Lysosomal Function

Glutamine is one of the most abundant amino acids in the cell. In mitochondria, glutaminases 1 and 2 (GLS1/2) hydrolyze glutamine to glutamate, which serves as the precursor of multiple metabolites. Here, we show that ammonium generated during GLS1/2-mediated glutaminolysis regulates lysosomal pH an...

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Detalles Bibliográficos
Autores principales: Xiong, Jian, Luu, Thi Thu Trang, Venkatachalam, Kartik, Du, Guangwei, Zhu, Michael X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9819001/
https://www.ncbi.nlm.nih.gov/pubmed/36611873
http://dx.doi.org/10.3390/cells12010080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9819001/
https://www.ncbi.nlm.nih.gov/pubmed/36611873
http://dx.doi.org/10.3390/cells12010080

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