Betulin Acid Ester Derivatives Inhibit Cancer Cell Growth by Inducing Apoptosis through Caspase Cascade Activation: A Comprehensive In Vitro and In Silico Study

Betulin, or naturally occurring triterpene, possesses promising antiproliferative activity. To further explore this potential, thirty-eight betulin acid ester derivatives modified at the C-28 position were tested for antitumor activities. Four human cancer cell lines, MV4-11 (leukemia), A549 (lung),...

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Detalles Bibliográficos
Autores principales: Pęcak, Paweł, Świtalska, Marta, Chrobak, Elwira, Boryczka, Grzegorz, Bębenek, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820118/
https://www.ncbi.nlm.nih.gov/pubmed/36613643
http://dx.doi.org/10.3390/ijms24010196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820118/
https://www.ncbi.nlm.nih.gov/pubmed/36613643
http://dx.doi.org/10.3390/ijms24010196

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